Van de Ven Brace Ends The Toffees' Unbeaten Streak at New Stadium
The Dutch defender became the initial backline player to score two goals in a English top-flight match for Spurs since Jan Vertonghen in March 2013.
Match summary
The Spurs defender heads into the net twice in opening period
Everton's Jake O'Brien has equalizer ruled after VAR review
Pape Matar Sarr nets final goal in dying moments
The defeat is Everton's first at their new ground
The Tottenham defender found the net twice as Tottenham extended their unbeaten run in away games in the Premier League and handed Everton their initial loss at their new home.
The Toffees were unbeaten in their five previous fixtures at their recently opened stadium at Bramley-Moore Dock, having departed their historic home behind after 133 years at the end of last season.
But Tottenham's leader the Dutchman struck twice from set-pieces in the first half to put their impressive record at jeopardy, and they were failed to turn it around before Pape Matar Sarr - assisted by ex-Everton forward Richarlison - headed home a third to put the game to bed.
The Everton defender thought he had equalized the tally a short while after Van de Ven's first goal, directing a powerful header past Guglielmo Vicario from an set-piece.
Beto, meanwhile, failed to convert a handful of chances, while the Italian goalkeeper made a series of fine saves to ensure the London club went five matches on the road unbeaten in the English top flight.
But the video assistant referee intervened, instructing the match official to review the score on the screen and the official ruled that the winger and the attacker were in an illegal position and had interfered with the Spurs keeper.
This victory moves Thomas Frank's side into third place in the division, five points off north London rivals and table-toppers the Gunners.
Everton stay 14th and sit half a dozen points clear of the relegation zone.
Tottenham analysis: The defender excels in duties at each end of the field
After a drab weekday performance in the Champions League against Monaco, where they managed a mere attempts on goal, the manager opted for Randal Kolo Muani up front instead of ex-Everton forward the Brazilian.
The summer signing was failed to influence the game before being substituted for Richarlison after 60 minutes on the field, but it turns out he wasn't needed in the end.
Centre-back Van de Ven transformed into an offensive threat to be feared.
Tottenham's first goal came from a well-worked set-piece play, with Rodrigo Bentancur directing the ball toward the six-yard box for an free the defender to head home.
And the captain - filling in as captain in the Argentine's unavailability - added his next goal in first-half stoppage time as he rose above the England keeper to head home.
The Dutchman was just as outstanding in defence, partnering effectively with Kevin Danso as the pair dealt superbly with the 34 crosses thrown their way by Everton.
Everton analysis: Everton lacking striker's instinct
The club's new home had been a fortress, but it appears the novelty may have worn off slightly and fans headed to the gates after Sarr's third for Spurs.
The end in the team's winning streak at home will not be a major concern for David Moyes, but their attacking woes will be.
Beto and the other striker - the Toffees' two established strikers - had netted just a single goal combined before the weekend's match.
And they were unable to contribute to that poor tally on a damp and dreary night on Merseyside.
Beto's form was epitomized when he opted to bicycle-kick a golden opportunity from close range, despite having room and opportunity to readjust for a simpler attempt that would have challenged the keeper.
The substitute, as well, was unable to make an impact after coming on for the starter in the 65th minute.
It wasn't for a shortage of chance. The majority of Everton's offensive moves came through the winger and Ndiaye, who relentlessly whipped threatening crosses into the Tottenham box.
What next for these two sides?
The Toffees: The team head to Sunderland in the top flight on Monday, 3 November at 8 PM.
Tottenham: Spurs go to St James' Park on Wednesday, 29 October for their next round Carabao Cup tie against Newcastle.